Hydroxychloroquine - What Goes On? | Page 8 | Australian Frequent Flyer
Australian Frequent Flyer

Welcome to Australia's leading independent Frequent Flyer and Travel Resource since 1998!
Our site contains tons of information that will improve your travel experience.

Joining AFF is fast, simple & absolutely free - register now and take immediate advantage of these great BENEFITS.

Once registered, this box will disappear. And you will see fewer advertisements :)

Login Now to remove this and all advertisements (GOLD and SILVER members)
Not a member? Register Now for free

Hydroxychloroquine - What Goes On?

Princess Fiona

Senior Member
Moderator
Joined
May 22, 2009
Messages
9,955
Qantas
Platinum 1
Flights
My Map
It is kind of hard to do a randomised trial of critical patients.

Their test of infected patients showed significantly quicker recovery times for those with hydroxychloroquine than those without.

Useful to know, if accurate, for further investigation, especially for forecasting times spent in treatment/hospital.
Regards,
Renato
On the contrary large multi-centre RCTs are frequently conducted in critically ill patients.
They are the cornerstone of quality clinical practice improvement.
 

Renato1

Established Member
Joined
May 1, 2015
Messages
1,679
Let me refresh you.



Sure, let's put these people who have been on Plaquenil successfully for years, on steroids for the duration and deal with that mess once Covid has long gone. And hope that in the meantime, they don't experience
  • liver disease, such as liver tumors and cysts.
  • kidney disease.
  • heart attack and stroke.
  • altered mood, irritability, increased aggression, depression or suicidal tendencies.
Painkillers? give me a break. Every lupus sufferer I know, and I know more than just 1, (😉) experiences arthritis. My niece in her late twenties, was using a walking stick at times. Until she started plaquenil. It wasn't until in her 30's that the markers for Lupus came through enough for the diagnosis of Lupus came through, before that, she was, as you flick off, merely an arthritis suffer. She did dreadfully on steroids. I was luckier, my markers turned to Lupus much quicker but I was older. Although maybe they were always there but not tested for.
Not sure what you are going on about.

I said it was fair enough the governors being concerned about people with Lupus, and you somehow - in a manner I do not understand - claim I had trivialised it by that statement?

Please explain again how I trivialized it, when I said it was fair enough to be concerned about it?
Regards,
Renato
Post automatically merged:

Still commonplace - I had 3 QC inspectors on their way to monitor industrial products just as the outbreak hit and all travel was stopped.
That's good to know, thanks.
Renato
 

Renato1

Established Member
Joined
May 1, 2015
Messages
1,679
Does Trump have shares in Sanofi as reported by NY Times?
No - he has money in a mutual fund, which as a small part of its portfolio, has shares in the drug company.

The anti-Trump New York Times loves clutching at straws.
Regards,
Renato
 

Renato1

Established Member
Joined
May 1, 2015
Messages
1,679
On the contrary large multi-centre RCTs are frequently conducted in critically ill patients.
They are the cornerstone of quality clinical practice improvement.
Did they do the randomised trials with crtically ill Ebola patients?
Just wondering if there were any souls brave enough.
Regards,
Renato
 

Renato1

Established Member
Joined
May 1, 2015
Messages
1,679
I went to my Doctor today to get my flu shot.

As we sat down he asked what he could do for me today.
I said "Have you got any of that Hydroxychloroquine?"
At which point he and I started laughing loudly.
Cheers,
Renato
 
  • Haha
Reactions: DC3

Renato1

Established Member
Joined
May 1, 2015
Messages
1,679
Yes there were several.
Here is one of themNEJM Ebola RCT
Thanks.
Is a randomised trial after infection and up to 28 days prior to death of some of the patients, what one would call a randomised trial of critical patients?
Can't see any difference between that and what the Chinese did with their randomised trial of infected patients with COvid 19, which you didn't think was critical.
Regards,
Renato
 

Pushka

Enthusiast
Joined
Jan 26, 2011
Messages
18,082
Flights
My Map
I went to my Doctor today to get my flu shot.

As we sat down he asked what he could do for me today.
I said "Have you got any of that Hydroxychloroquine?"
At which point he and I started laughing loudly.
Cheers,
Renato
Unless he prescribed it for you when there were nefarious practices being done (shame on those professionals - they should send them to the front lines, assuming they'd be "welcome"); that does mean you won't get it now.

Lets leave it up to the professional researchers to get the trial done hey?
 
Joined
Jul 10, 2007
Messages
359
Flights
My Map
Lots of people writing in to the papers advocating the herd immunity approach i.e. infect the young to build up resistance to protect the rest of us. Here's an idea - charter a cruise ship then call for a couple of thousand young, healthy volunteers. Add one Covid-19 positive crew member, then sail away for a month or so. Any takers?
 

Princess Fiona

Senior Member
Moderator
Joined
May 22, 2009
Messages
9,955
Qantas
Platinum 1
Flights
My Map
Thanks.
Is a randomised trial after infection and up to 28 days prior to death of some of the patients, what one would call a randomised trial of critical patients?
Can't see any difference between that and what the Chinese did with their randomised trial of infected patients with COvid 19, which you didn't think was critical.
Regards,
Renato
Half of the patients died.
I think their illness was critical.

There are numerous examples of RCTs for treatment of ARDS etc in the critical care literature.
 
Joined
Jul 13, 2006
Messages
6,894
Unless he prescribed it for you when there were nefarious practices being done (shame on those professionals - they should send them to the front lines, assuming they'd be "welcome"); that does mean you won't get it now.

Lets leave it up to the professional researchers to get the trial done hey?
It is odd the need that some have to gloat on trying to get what they should not have.
 

Pushka

Enthusiast
Joined
Jan 26, 2011
Messages
18,082
Flights
My Map
It is odd the need that some have to gloat on trying to get what they should not have.
I suspect, sadly, that such people already have a stash. Leaving many who need that treatment, meaning that they are begging on FB for others to share their correctly prescribed medicine. Or driving around fruitlessly finding supplies anywhere.
 

mrs.dr.ron

Established Member
Joined
Jun 17, 2010
Messages
1,336
Brisbane Times this morning =

Doctors who prescribe an anti-malarial drug being trumpeted as a potential COVID-19 treatment face a $13,000 fine.

New prescription rules, brought into effect in Queensland on Tuesday, mean clinicians are banned from prescribing the drug, hydroxychloroquine, as a COVID-19 treatment.
Hydroxychloroquine is an anti-malarial now used to treat autoimmune conditions such as lupus and rheumatoid arthritis.
There is no solid evidence it is effective against COVID-19, but federal Health Minister Greg Hunt said there had been “some promising research so far”.

The new law, introduced under public health powers granted to the state's top doctor, Chief Health Officer Jeannette Young, is also aimed at stopping pharmacies and GP clinics from stockpiling the medication.

Under the public health order, only some specialists are allowed to prescribe the drug and it must be for the ongoing treatment of a chronic disease or as part of a clinical trial.
The University of Queensland is on the verge of starting a large clinical trial, involving 60 hospitals across Australia, with hydroxychloroquine and another a HIV medication.
 

kyle

Established Member
Joined
Mar 8, 2006
Messages
1,052
I was able to fill a script yesterday for plaquenil. Yay me. I can go back to proper dose now as I'd cut back just in case. Newest bottle is manufactured by Sanofi and states Plaquenil. Old bottle was generics, Apo-hydroxychloroquine produced by Apotek so something has changed.

Does Trump have shares in Sanofi as reported by NY Times?
I always asked for the original, so it's always been Plaquenil by Sanofi.
 
Joined
Jul 10, 2007
Messages
359
Flights
My Map
From The Limbic, a medical newletter:

"Cardiologists have warned of the need to monitor for cardiac complications of hydroxychloroquine if it is used as a treatment for COVID-19 disease.


As Australia starts clinical trials of the drug and the government approves off label use of hydroxychloroquine for COVID-19, clinicians in France say they found the arrhythmia risks of the drug to be excessive for some patients.


Professor Émile Ferrari, heads of the cardiology department at the Pasteur Hospital said they had stopped using a hydroxychloroquine-azithromycin regime in patients with COVID-19 after ECG monitoring revealed cardiac toxicity.


He told the news outlet Nice Matin that the trial protocol stipulated ECG monitoring of patients at baseline and during the first two days of treatment.


“From the start of the trial, thanks to this ECG follow-up, we highlighted major risks of very serious [adverse events] in patients, and the treatment was immediately stopped,” he said.


Prof Ferrari said the cardiac risks of hydroxychloroquine were potentiated when used in combination with the azithromycin, which is also known to increase the risk of QT prolongation and cardiovascular death.


The cardiac toxicity may be further increased in patients with COVID-19 disease if they have low blood oxygenation or disordered potassium levels, he added."

But what would he know?
 

tgh

Established Member
Joined
Apr 23, 2006
Messages
1,970
I read a really interesting lay piece this morning , with some really interesting prognostications about how the bug works and malaria drugs.
If i manage to find any science links to the concept I will post them.
Of course there is so much pseudo science about that one might indeed conclude that the 5g network has something to do with it all.
 

drron

Enthusiast
Joined
Jul 4, 2002
Messages
21,710
The usual generic v patent expired original.
The functional ingredients should be identical
But not always.Though the ones who produce dodgy drugs-usually India-are known and shouldn't get their products into Australia.
But there is this famous case.
 

Community Statistics

Threads
85,704
Messages
2,035,376
Members
52,960
Latest member
Jan Coetzee
Top