Hydroxychloroquine - What Goes On?

Renato1

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I like watching Fox News.

Last Monday, on his radio show, Hannity interviewed a Doctor in a New York hotspot. Doctor said, he treated 350 patients of his and 150 in another area with hydroxychloroquine, antibiotics and zinc sulfate . At that time, he had had none going to hospital and none dead.

Next day Hannity had another New York doctor on who was also treating his patients with hydroxychloroquine - he was more coy about citing facts and figures, but said his results from using the anti-malaria drug on patients were positive.

On Saturday, Tucker Carlson had another doctor on describing the nightmare in New York hospitals. The Doctor then stated that he was using the anti-malaria drug as a prophylactic.

And New York Governor Cuomo was procuring 750,000 doses of the malaria drug chloroquine; 70,000 doses of its derivative, hydroxychloroquine; and 10,000 doses of the antibiotic Zithromax.

After President Trump expressed optimism over the results that French doctors had gotten with the drugs, and he had ordered the FDA to fast track testing of hydroxychloroquine, the Governors of Nevada and Michigan then passed orders preventing their doctors from using hydroxychloroquine on their patients,

These reports sort of raised a lot of questions to me like -
Would it not be a simple statistical test to see if, on contracting the virus, the population of people currently taking the drug for Lupus and arthritis have a significantly lower hospitalisation and death rate than the general population?

Would it not be a simple statistical test to compare the hundreds already treated with the drugs after contracting the virus, to an equivalent number of people who contracted the virus a few weeks prior who weren't treated?

What's up with those State Governors banning its use? and

Is the drug useless, or are New Yorkers and people here and in other countries now dying needlessly?

Then, on The Bolt Report tonight, he reported that New York health workers are now on the anti-malaria drug.
And that France and Italy now allows it to be used in some cases.
And that our health workers will be starting a trial in three weeks.

So, is this some kind of Right Wing Conspiracy in presenting the information above?
Or, does a partial cure fo rthe epidemic exist, but it doesn't work for the public ......but it is good for health workers? (Kind of reminds me of our Face Mask discussion)

Any thoughts?
Regards,
Renato
 
It is kind of hard to do a randomised trial of critical patients.

Their test of infected patients showed significantly quicker recovery times for those with hydroxychloroquine than those without.

Useful to know, if accurate, for further investigation, especially for forecasting times spent in treatment/hospital.
Regards,
Renato
On the contrary large multi-centre RCTs are frequently conducted in critically ill patients.
They are the cornerstone of quality clinical practice improvement.
 
Let me refresh you.



Sure, let's put these people who have been on Plaquenil successfully for years, on steroi_s for the duration and deal with that mess once Covid has long gone. And hope that in the meantime, they don't experience
  • liver disease, such as liver tumors and cysts.
  • kidney disease.
  • heart attack and stroke.
  • altered mood, irritability, increased aggression, depression or suicidal tendencies.
Painkillers? give me a break. Every lupus sufferer I know, and I know more than just 1, (😉) experiences arthritis. My niece in her late twenties, was using a walking stick at times. Until she started plaquenil. It wasn't until in her 30's that the markers for Lupus came through enough for the diagnosis of Lupus came through, before that, she was, as you flick off, merely an arthritis suffer. She did dreadfully on steroi_s. I was luckier, my markers turned to Lupus much quicker but I was older. Although maybe they were always there but not tested for.
Not sure what you are going on about.

I said it was fair enough the governors being concerned about people with Lupus, and you somehow - in a manner I do not understand - claim I had trivialised it by that statement?

Please explain again how I trivialized it, when I said it was fair enough to be concerned about it?
Regards,
Renato
Post automatically merged:

Still commonplace - I had 3 QC inspectors on their way to monitor industrial products just as the outbreak hit and all travel was stopped.
That's good to know, thanks.
Renato
 
Does Trump have shares in Sanofi as reported by NY Times?
No - he has money in a mutual fund, which as a small part of its portfolio, has shares in the drug company.

The anti-Trump New York Times loves clutching at straws.
Regards,
Renato
 
On the contrary large multi-centre RCTs are frequently conducted in critically ill patients.
They are the cornerstone of quality clinical practice improvement.
Did they do the randomised trials with crtically ill Ebola patients?
Just wondering if there were any souls brave enough.
Regards,
Renato
 
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I went to my Doctor today to get my flu shot.

As we sat down he asked what he could do for me today.
I said "Have you got any of that Hydroxychloroquine?"
At which point he and I started laughing loudly.
Cheers,
Renato
 
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Yes there were several.
Here is one of themNEJM Ebola RCT
Thanks.
Is a randomised trial after infection and up to 28 days prior to death of some of the patients, what one would call a randomised trial of critical patients?
Can't see any difference between that and what the Chinese did with their randomised trial of infected patients with COvid 19, which you didn't think was critical.
Regards,
Renato
 
I went to my Doctor today to get my flu shot.

As we sat down he asked what he could do for me today.
I said "Have you got any of that Hydroxychloroquine?"
At which point he and I started laughing loudly.
Cheers,
Renato
Unless he prescribed it for you when there were nefarious practices being done (shame on those professionals - they should send them to the front lines, assuming they'd be "welcome"); that does mean you won't get it now.

Lets leave it up to the professional researchers to get the trial done hey?
 
Lots of people writing in to the papers advocating the herd immunity approach i.e. infect the young to build up resistance to protect the rest of us. Here's an idea - charter a cruise ship then call for a couple of thousand young, healthy volunteers. Add one Covid-19 positive crew member, then sail away for a month or so. Any takers?
 
Thanks.
Is a randomised trial after infection and up to 28 days prior to death of some of the patients, what one would call a randomised trial of critical patients?
Can't see any difference between that and what the Chinese did with their randomised trial of infected patients with COvid 19, which you didn't think was critical.
Regards,
Renato
Half of the patients died.
I think their illness was critical.

There are numerous examples of RCTs for treatment of ARDS etc in the critical care literature.
 
Unless he prescribed it for you when there were nefarious practices being done (shame on those professionals - they should send them to the front lines, assuming they'd be "welcome"); that does mean you won't get it now.

Lets leave it up to the professional researchers to get the trial done hey?

It is odd the need that some have to gloat on trying to get what they should not have.
 
It is odd the need that some have to gloat on trying to get what they should not have.
I suspect, sadly, that such people already have a stash. Leaving many who need that treatment, meaning that they are begging on FB for others to share their correctly prescribed medicine. Or driving around fruitlessly finding supplies anywhere.
 
Brisbane Times this morning =

Doctors who prescribe an anti-malarial drug being trumpeted as a potential COVID-19 treatment face a $13,000 fine.

New prescription rules, brought into effect in Queensland on Tuesday, mean clinicians are banned from prescribing the drug, hydroxychloroquine, as a COVID-19 treatment.
Hydroxychloroquine is an anti-malarial now used to treat autoimmune conditions such as lupus and rheumatoid arthritis.
There is no solid evidence it is effective against COVID-19, but federal Health Minister Greg Hunt said there had been “some promising research so far”.

The new law, introduced under public health powers granted to the state's top doctor, Chief Health Officer Jeannette Young, is also aimed at stopping pharmacies and GP clinics from stockpiling the medication.

Under the public health order, only some specialists are allowed to prescribe the drug and it must be for the ongoing treatment of a chronic disease or as part of a clinical trial.
The University of Queensland is on the verge of starting a large clinical trial, involving 60 hospitals across Australia, with hydroxychloroquine and another a HIV medication.
 
I was able to fill a script yesterday for plaquenil. Yay me. I can go back to proper dose now as I'd cut back just in case. Newest bottle is manufactured by Sanofi and states Plaquenil. Old bottle was generics, Apo-hydroxychloroquine produced by Apotek so something has changed.

Does Trump have shares in Sanofi as reported by NY Times?

I always asked for the original, so it's always been Plaquenil by Sanofi.
 
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From The Limbic, a medical newletter:

"Cardiologists have warned of the need to monitor for cardiac complications of hydroxychloroquine if it is used as a treatment for COVID-19 disease.


As Australia starts clinical trials of the drug and the government approves off label use of hydroxychloroquine for COVID-19, clinicians in France say they found the arrhythmia risks of the drug to be excessive for some patients.


Professor Émile Ferrari, heads of the cardiology department at the Pasteur Hospital said they had stopped using a hydroxychloroquine-azithromycin regime in patients with COVID-19 after ECG monitoring revealed cardiac toxicity.


He told the news outlet Nice Matin that the trial protocol stipulated ECG monitoring of patients at baseline and during the first two days of treatment.


“From the start of the trial, thanks to this ECG follow-up, we highlighted major risks of very serious [adverse events] in patients, and the treatment was immediately stopped,” he said.


Prof Ferrari said the cardiac risks of hydroxychloroquine were potentiated when used in combination with the azithromycin, which is also known to increase the risk of QT prolongation and cardiovascular death.


The cardiac toxicity may be further increased in patients with COVID-19 disease if they have low blood oxygenation or disordered potassium levels, he added."

But what would he know?
 
I read a really interesting lay piece this morning , with some really interesting prognostications about how the bug works and malaria drugs.
If i manage to find any science links to the concept I will post them.
Of course there is so much pseudo science about that one might indeed conclude that the 5g network has something to do with it all.
 
The usual generic v patent expired original.
The functional ingredients should be identical
But not always.Though the ones who produce dodgy drugs-usually India-are known and shouldn't get their products into Australia.
But there is this famous case.
 

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