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Hydroxychloroquine - What Goes On?

teammongo

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To give some perspective, those who are medical will understand this.

We have a COVID patient on the hydroxychloroquine whose QTc is 600. Normally this would be very worrying.
 

dajop

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But not always.
Yes, in my industry (not pharmaceutical, but not dissimilar) there are multinational R&D players and respected generic players (both local and multinational) who all produce high quality material, after that there's some OK importers and from there a race to the bottom where the criminals lurk ....
 

Pushka

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To give some perspective, those who are medical will understand this.

We have a COVID patient on the hydroxychloroquine whose QTc is 600. Normally this would be very worrying.
Is there something I should be on the lookout for with this heart issue? I had an ecg when I had the DVT due to location but not one since I've been on the plaquenil.
 

drron

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One of the things I did when I prescribed plaquenil was to get an ECG before starting to see if there was QT prolongation-if there was became a little hesitant to start it.Then a while after starting a repeat ECG to see if any change.If the QT segment remained normal no problems.
With the eye side effects an annual eye examination.but studies suggest if you keep the dose less than 500mg per day the eye problems are rare.
 

Tamerton

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I have read in some cheaper generic brand medications the active ingredient is not as refined as it could be and is not as readily utilised by the body.
Therefore may not work as well as the more expensive brand name medication. Something to think about. Generic may not work as well as the expensive drug.
 

Tamerton

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Also the paper provided by the French Doctor Regarding hydroxychloroquine treatment of Covid is questionable with quiet a few holes in it. He has also produced previous papers that have left a lot of questions.
With the data supplied in this paper I don’t think it can be relied upon.

 

Pushka

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I have read on Lupus forums that many wont accept the generic version and only the original but goodness knows if that has been verified and not just the placebo effect.
 

moa999

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Brazillian study.
Only looks like the high dosage arm of the study has been stopped
 

drron

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Though both the high dose and the low dose regimens in that trial are higher doses than used and recommended for SLE.
Hard to know if it was truly ineffective as some in the treatment arm may well have died of the treatment than the disease.

A couple more articles.

And a very interesting basic science article on the virus.

 

pauly7

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drron

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Some Swedish hospitals have opted to stop using it.

Well the reports of visual loss are surprising.Yes a well known side effect but it usually takes a year or more to develop and rare if the dose is under 500mg per day.I suspect a nocebo effect could be going on.That is some people told of the side effects then develop them.I well remember one young woman, who really didn't want to take medication for epilepsy, telling me the drug had caused a loss of libido and increased sexual urges.Yes both were listed on the CPI sheet provided with the drug.
 

Pushka

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Well the reports of visual loss are surprising.Yes a well known side effect but it usually takes a year or more to develop and rare if the dose is under 500mg per day.I suspect a nocebo effect could be going on.That is some people told of the side effects then develop them.I well remember one young woman, who really didn't want to take medication for epilepsy, telling me the drug had caused a loss of libido and increased sexual urges.Yes both were listed on the CPI sheet provided with the drug.
Agree re the issue of vision. I thought it was over a period of years that deposits occur but regular checking establishes a baseline.
Did you need to suppress a chuckle at the libido thing?
 

lovetravellingoz

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The next article after this one from the Daily Mail was ‘Is Batman real?? Photos surface!!’

Perhaps but there were multiple reports of some Swedish hospitals stopping their trials. I only bothered to post one.



 
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dajop

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So would the conclusion of all this stand that "the jury is still out" on this "beautiful" drug?
 
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