Hydroxychloroquine - What Goes On?

Renato1

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I like watching Fox News.

Last Monday, on his radio show, Hannity interviewed a Doctor in a New York hotspot. Doctor said, he treated 350 patients of his and 150 in another area with hydroxychloroquine, antibiotics and zinc sulfate . At that time, he had had none going to hospital and none dead.

Next day Hannity had another New York doctor on who was also treating his patients with hydroxychloroquine - he was more coy about citing facts and figures, but said his results from using the anti-malaria drug on patients were positive.

On Saturday, Tucker Carlson had another doctor on describing the nightmare in New York hospitals. The Doctor then stated that he was using the anti-malaria drug as a prophylactic.

And New York Governor Cuomo was procuring 750,000 doses of the malaria drug chloroquine; 70,000 doses of its derivative, hydroxychloroquine; and 10,000 doses of the antibiotic Zithromax.

After President Trump expressed optimism over the results that French doctors had gotten with the drugs, and he had ordered the FDA to fast track testing of hydroxychloroquine, the Governors of Nevada and Michigan then passed orders preventing their doctors from using hydroxychloroquine on their patients,

These reports sort of raised a lot of questions to me like -
Would it not be a simple statistical test to see if, on contracting the virus, the population of people currently taking the drug for Lupus and arthritis have a significantly lower hospitalisation and death rate than the general population?

Would it not be a simple statistical test to compare the hundreds already treated with the drugs after contracting the virus, to an equivalent number of people who contracted the virus a few weeks prior who weren't treated?

What's up with those State Governors banning its use? and

Is the drug useless, or are New Yorkers and people here and in other countries now dying needlessly?

Then, on The Bolt Report tonight, he reported that New York health workers are now on the anti-malaria drug.
And that France and Italy now allows it to be used in some cases.
And that our health workers will be starting a trial in three weeks.

So, is this some kind of Right Wing Conspiracy in presenting the information above?
Or, does a partial cure fo rthe epidemic exist, but it doesn't work for the public ......but it is good for health workers? (Kind of reminds me of our Face Mask discussion)

Any thoughts?
Regards,
Renato
 
Yes the jury is still out.Larger trials are needed for greater accuracy.As well I believe the larger trials are using a more normal dose of plaquenil-200mg twice a day where the low dose group in Switzerland was getting 450mg twice a day.
 
Yes the jury is still out.Larger trials are needed for greater accuracy.As well I believe the larger trials are using a more normal dose of plaquenil-200mg twice a day where the low dose group in Switzerland was getting 450mg twice a day.

And to determine what dosage, if any , actually works, whether by itself or in combination with other drugs. And also what if any side effects occur and how harmful they are if hey do.
 
And to determine what dosage, if any , actually works, whether by itself or in combination with other drugs. And also what if any side effects occur and how harmful they are if hey do.
At 200mg bd there has been over 40 years of experience with the side effects as I have previously posted.That is why the recommendation now is a dose less than 500mg per day.
 
They need to be bioequivalent. Please don't spread fake news.

From my own experience, I take another drug which I need to cut into 1/4 myself. One time the pharmac_ ran out of the original, so I was given a generic. When I cut the generic into 1/4, none of them would cut cleanly with the pill cutter. Lesson for me is, while the ingredients may be the same, its construction or base is different.

I also like supporting the original because I believe they've spent the R & D on it, so should be entitled to the profits.
 
From my own experience, I take another drug which I need to cut into 1/4 myself. One time the pharmac_ ran out of the original, so I was given a generic. When I cut the generic into 1/4, none of them would cut cleanly with the pill cutter. Lesson for me is, while the ingredients may be the same, its construction or base is different.

I also like supporting the original because I believe they've spent the R & D on it, so should be entitled to the profits.
I was commenting on the active ingredient delivery, not the excipients. Originator brands viz Pfizer, Novartis, Roche, Merck, GSK are not exactly doing it tough. Bioequivalent generics save our PBS hundreds of $M each year. Our TGA is one of the toughest regulators in the world (fortunately). Most API (Active Pharmaceutical Ingredients) are made by a handful of companies that most have never heard of.
 
Self sourcing is not such a good idea, and moreso when you do not really understand what it is anyway....

Come on that has been discussed on here already.They drank fish tank cleaner for heaven's sake.Very unlikely to have been the chloroquine that killed them.
 
Come on that has been discussed on here already.They drank fish tank cleaner for heaven's sake.Very unlikely to have been the chloroquine that killed them.

What do you mean by come on?? What is unclear in " Self sourcing is not such a good idea, and moreso when you do not really understand what it is anyway.... "

My point was that self-sourcing when you do not even understand what it is is not a good idea. And yes I read what they took or I would not have posted it and what they took was the whole point of my post.



PS Apologies if it was a repeat of what others have posted..
 
PBS data has lots of answers. Still no-one making use of it? Not using it sugegsts they want is to spread asymptomatically withot too many deaths or expensive hospital interventions. The cost beneft analysis of plasma transfusions gets better and better.
 
That trial looks like unnecessary duplication, that French doctor keeps growing the sample size.
I think there is enough empircal evidence that the former saves lives and cheap and effective. Now patient compliance in takingt he whole course, and what if they dont - well that is a concern.

The resodmir? trial put out a fantasic pump press release, but organ failure, 25% dead kidneys - are pretty big negatives!

PBS data: For everyone taking HCQfor whatever reason(lupus) have any of these tested positive for corona. Repeat worldwide?
 
Your position is that social distancing works in among groups of people visiting stores, visiting doctors, visiting pharmacies - but amazingly doesn't work when practiced on the beach or in a park. Oddly enough, on tonights' program Andrew Bolt seems to be as astounded as I am with this sort of strange thinking.
@Renato1 I enjoy your posts and your thinking but let me tell you something about people/humans in general.

We are awful. We don't follow advice and we are selfish.

My wife, my daughter and myself, we went for a walk today from Toowong to Brisbane City via the Brisbane River walkway. Over 8,000 steps. We did not overtake anyone. Everybody overtook us.

There are bikes going up and down, scooters and skateboards. The walking track is probably 2 metres across at the most. You can probably fit 3 people casually walking across. My wife was walking in front, my daughter walking behind her and me 3-4 metres behind with the stroller.

I was stunned at the number of pairs walking past us either way and continuing to walk side by side. FFS. It's not that difficult to step back single file as you pass. In fact some decided they'll overtake by walking on the bike track and almost touched shoulders as they passed my wife. FFS.

And it's not just one or two. There were many doing it today. I don't trust people. I said to my wife we need to carefully consider whether we do this walk again. We usually walk an hour in the evenings and there are hardly any people around.
 
@Renato1 I enjoy your posts and your thinking but let me tell you something about people/humans in general.

We are awful. We don't follow advice and we are selfish.

My wife, my daughter and myself, we went for a walk today from Toowong to Brisbane City via the Brisbane River walkway. Over 8,000 steps. We did not overtake anyone. Everybody overtook us.

There are bikes going up and down, scooters and skateboards. The walking track is probably 2 metres across at the most. You can probably fit 3 people casually walking across. My wife was walking in front, my daughter walking behind her and me 3-4 metres behind with the stroller.

I was stunned at the number of pairs walking past us either way and continuing to walk side by side. FFS. It's not that difficult to step back single file as you pass. In fact some decided they'll overtake by walking on the bike track and almost touched shoulders as they passed my wife. FFS.

And it's not just one or two. There were many doing it today. I don't trust people. I said to my wife we need to carefully consider whether we do this walk again. We usually walk an hour in the evenings and there are hardly any people around.
Hi John,
Thanks. I suspect that people in Brisbane are subconciously aware that the heat and sun zaps any virus floating around in mid air. Might be the reason there are only four cases in the Cairns area - where my wife and I were meant to be going on vacation in June.

Down here in Melbourne - when we still had sunny weather and could use beaches - people were drawing big 1.5 meter circles around them in the sand while sunbaking. And the road in front of my house has a very popular walking path on it, and I see people pretty well spaced apart on it. And in my travels, I can't honestly say I've seen people walking close together in the manner you describe (but maybe I'm not in the right part of town). Could be that we are a bit different from Brisbane and more sensitive to the onset of wet, dank, miserable, cold weather down here - nothing to zap floating virus.
Cheers,
Renato
 
PBS data: For everyone taking HCQfor whatever reason(lupus) have any of these tested positive for corona. Repeat worldwide?
Yes, I've already answered that a couple of times before. On a Lupus FB there have been a few reports of people in Australia contracting Covid on HCQ. They recovered well and did not experience any major illness.
 
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@Renato1 I enjoy your posts and your thinking but let me tell you something about people/humans in general.

We are awful. We don't follow advice and we are selfish.

My wife, my daughter and myself, we went for a walk today from Toowong to Brisbane City via the Brisbane River walkway. Over 8,000 steps. We did not overtake anyone. Everybody overtook us.

There are bikes going up and down, scooters and skateboards. The walking track is probably 2 metres across at the most. You can probably fit 3 people casually walking across. My wife was walking in front, my daughter walking behind her and me 3-4 metres behind with the stroller.

I was stunned at the number of pairs walking past us either way and continuing to walk side by side. FFS. It's not that difficult to step back single file as you pass. In fact some decided they'll overtake by walking on the bike track and almost touched shoulders as they passed my wife. FFS.

And it's not just one or two. There were many doing it today. I don't trust people. I said to my wife we need to carefully consider whether we do this walk again. We usually walk an hour in the evenings and there are hardly any people around.
I will always overtake slower moving groups in front of me. Always. However, I do notice this peculiar thing that people walking towards me have to correct space between each other, then as they pass me, they come so close - to a stranger? WT is that all about.

Another time there was a couple walking towards us and we were both able to maintain a space as we passed. Well, we did except for the bluddy cyclist who was a woman my age who took that gap to ride between us knocking us both. She wore some abuse from me.
 
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I will always overtake slower moving groups in front of me. Always. However, I do notice this peculiar thing that people walking towards me have to correct space between each other, then as they pass me, they come so close - to a stranger? WT is that all about.

Another time there was a couple walking towards us and we were both able to maintain a space as we passed. Well, we did except for the bluddy cyclist who was a woman my age who took that gap to ride between us knocking us both. She wore some abuse from me.
The cyclists and runners are aerosolising big time. I'm opting for the relatively empty streets. The view is not as good but the air is less breathy.
 
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