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Hydroxychloroquine - What Goes On?

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What are the ethical considerations regarding anonymous online medical practitioners advocating novel, untested off label indications for old drugs with known toxicity?
 

drron

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What are the ethical considerations regarding anonymous online medical practitioners advocating novel, untested off label indications for old drugs with known toxicity?
Virtually everything you put in your mouth can be toxic.
People die from anaphylaxis eating nuts,strawberries shellfish.
I have seen a person die from drinking too much water-psychogenic polydipsia.

So drugs are no different.Hydroxychloroquine has been used for nearly 70 years so it's side effects are pretty well known.When using any drug at the very least the serious side effects should be discussed with the patient as well as what you might think could be achieved.
Remember side effects do not affect everyone who takes the drug.The vast majority of patients take hydroxychloroquine without any side effects.The commonest are not serious-taste and nausea etc.
The most serious side effect in numbers is retinopathy with series showing 11.5% of patients using it for over 16 years may get this so annual eye examinations need to be done.
Nearly 5 years ago a new recommendation was made to reduce the maximum dose to 5mg per KG.Using this level the incidence falls to ~ 1%.
.

Hydroxychloroquine is on the WHO list of essential medicines.
 

TheRealTMA

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Another prospective which reflects views of some in this discussion.

 

Pushka

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Another prospective which reflects views of some in this discussion.

Clearly Lupus sufferers just need to consult Renato1 who would prescribe a bex and a good lie down.
 

Vic

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It is simple - compare the first Doctor mentioned who has an entire population of size 500, which was treated with hydroxychoroquine, to that of another Doctor in the same area with similar type patients who has treated an equivalent number of patients without it - and compare the results.

Look for anything in the two populations that may skew the results and make the populations atypical (e.g. comparing affluent patients with one doctor to low socio-economic types with the other)
Regards,
Renato
The first group has a chronic serious illness, How do you correct for that in a healthy group? The underlying reason the first group is getting hydroxychoroquine can certainly skew the results.

No Trump did not say they cured Covid.He said he wanted them to be used now.The FDA approved the use for Covid for trials and Compassionate use on 19/3.
Also one person died after drinking fish tank cleaner which contains Quinine.Trump said nothing about Quinine.So he did not cause deaths.
Trump has also built a stockpile of Hydroxychloroquine-2 drug companies have donated 50 million tablets.

You also hear what you want to hear and take the things stated in the MSM as fact when they definitely are not always so.
No not quinine. The fish tank cleaner contained chloroquine phosphate.

chloroquine is name trump used.
 

drron

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No not quinine. The fish tank cleaner contained chloroquine phosphate.

chloroquine is name trump used.
He didn't say fish tank cleaner.for heaven's sake. You really don't believe that he caused the deaths.The media reported that fish tank cleaner contained the drug yet You aren't blaming them are you.
Please drop this ridiculous bias.
 

Vic

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He didn't say fish tank cleaner.for heaven's sake. You really don't believe that he caused the deaths.The media reported that fish tank cleaner contained the drug yet You aren't blaming them are you.
Please drop this ridiculous bias.
I never said anything about naming fish tank cleaner.
Really not sure why you need to be obtuse, and hyperbolic in defending him.

I made a simple correction, Trump did not say Quinine, as you claimed. He said a chemical name, that matched the ingredients on the bottle. I think the bias here is with the person going off on a rant, on wrong information, to defend trump
 

straitman

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We used Chloroquine for Malaria prevention in my Air Force days. We quickly learnt that it had some severe limitations.

It made the odd person sick (ie throw up) through to occasionally not working at all. My brother in law was flying a Caribou somewhere way north of Darwin when he collapsed at the controls and nearly died. He had developed Malaria despite the medication.
 

Pushka

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We used Chloroquine for Malaria prevention in my Air Force days. We quickly learnt that it had some severe limitations.

It made the odd person sick (ie throw up) through to occasionally not working at all. My brother in law was flying a Caribou somewhere way north of Darwin when he collapsed at the controls and nearly died. He had developed Malaria despite the medication.
I did read it was discontinued for malaria prevention as the bug became resistant. Goodness, I'm glad I don't get these side effects. It can affect the heart, can't it? That's interesting. The Rheumatologist always does a very thorough "heart" exam too.

Goodness, I need take a bex and lie down. (I'm not very forgiving at the moment; just a warning 😤)
 

Vic

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Can you even buy bex these days?
Nope, unfortunately. I remeber the boxes of bex at my grandmas place. Read the ingredients when much older and realised I'd missed out of some good stuff.
 

Pushka

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Nope, unfortunately. I remeber the boxes of bex at my grandmas place. Read the ingredients when much older and realised I'd missed out of some good stuff.
Do tell. What is in it then? I thought it was just a basic aspirin. Dammit, maybe Renato1 was on to a good thing?
 

Vic

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Do tell. What is in it then? I thought it was just a basic aspirin. Dammit, maybe Renato1 was on to a good thing?
My memory says it was basically cocaine and speed and herion all in one. But that's not right, just that it was highly addictive. The yanks sell some good painkillers that include caffeine...

From some pharmacy page:

Addiction to APC powders was common, with high rates of addiction in New South Wales and Queensland particularly.3 The dosages in Bex powder are one indication of the reason for its addictive qualities and its toxicity, with some formulations containing 420 mg of aspirin, 420 mg of phenacetin and 160 mg of caffeine in a single dose.4

And from Wikipedia Bex (compound analgesic) - Wikipedia

Bex was a strong compound analgesic which was popular in Australia for much of the twentieth century. It came in the form of APC (aspirinphenacetincaffeine) tablets or powder, containing 42% aspirin, 42% phenacetin, plus caffeine.[1]
 

mrs.dr.ron

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Geez, I remember BEX - when I was a young girl ( a very long time ago ) my grandfather used to take a BEX with his cup of tea at 10am everyday - just in case he got a headache :rolleyes: It was a pretty pink powder !!

It was the phenacetin that was addictive and a kidney killer !
 

Pushka

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Geez, I remember BEX - when I was a young girl ( a very long time ago ) my grandfather used to take a BEX with his cup of tea at 10am everyday - just in case he got a headache :rolleyes: It was a pretty pink powder !!

It was the phenacetin that was addictive and a kidney killer !
Pink. I remember that. Clearly my granny used it. In a sweet little navy blue box.
 

OATEK

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My memory says it was basically cocaine and speed and herion all in one. But that's not right, just that it was highly addictive. The yanks sell some good painkillers that include caffeine...

From some pharmacy page:

Addiction to APC powders was common, with high rates of addiction in New South Wales and Queensland particularly.3 The dosages in Bex powder are one indication of the reason for its addictive qualities and its toxicity, with some formulations containing 420 mg of aspirin, 420 mg of phenacetin and 160 mg of caffeine in a single dose.4

And from Wikipedia Bex (compound analgesic) - Wikipedia

Bex was a strong compound analgesic which was popular in Australia for much of the twentieth century. It came in the form of APC (aspirinphenacetincaffeine) tablets or powder, containing 42% aspirin, 42% phenacetin, plus caffeine.[1]
My dance teacher had a few too many Bex leading to a very long lie down. Renal failure I think, and premature death of someone otherwise so very fit (she had amazing energy on the dance floor).
 

TheRealTMA

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Can you even buy bex these days? I shall have a try. I might tell the pharmacist to stop reserving me a bottle of plaquenil when it comes in and I will just take Bex instead. Might be fun filming the reaction
No, it was banned in 1977 because it contains the somewhat nasty phenacetin .

1585711268548.png
 

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