Doesn't make the AZ vaccine look that good, really. 88% vs 60%,
This Blood group theory is very un-scientific, but so is singling out indigenous tribes without any hard evidence for special treatment. Between HIT and Covid shots, blood type risk analysis should be showing up.Here is the 4th in the series with Alan Cheng talking about blood clots and AZ.
I have been able to do this as the college now allows direct access to everybody.Unfortunately it does make the info a bit out of date.
Just a possible reason why AZ might still become the most used vaccine.The clotting issue is very similiar to that caused by Heparin.A study in the USA showed that American Indians had double the chance of developing this but all other patients were white.No cases found in any other minority.It is quite probable this is a genetic problem hence possible that most of the world may be able to use it without problems.
Real world results show Pfizer more effective qgainst Indian and UK variants than Astra Zeneca.
A double dose of COVID-19 vaccines is almost as effective against the fast-spreading variant of the coronavirus first identified in India as it is against Britain's dominant strain, English health officials said on Saturday.www.ctvnews.ca
And by implication, moronic politicians and State premiers saying 1.6% is too much to talk about home quarantine or overseas flights, and on arrival test(s). And now evidence, that 12 months on, protection is still good or improved. I would argue people who got their AZ shots early, are the socially responsible sorts, and that everyone fully vaccinated before the October election is called, gets to go OS, like the rest of the civilized world, bar places where airline groundings are foreseen.And I have already quoted an Indian study of health care workers fully vaccinated with the AZ vaccine showing 98.4% effectiveness against symptomatic and asymptomatic disease.
You can't have the vaccine if you have an active infection. Generally if you are there to be tested there is a chance you might have it, so ...Why don't they combine the testing & vaccine sites into one? Get tested, get first jab?
Melbourne is on the brink of another major lock down - again.
You can't have the vaccine if you have an active infection.
Oh, my bad. I must have been thinking about Remdesivir or something like that.
Interesting that Victoria has opened up to anyone over the age of 40 for the vaccine (Pfizer/BioNTech)
Phone lines jammed - swamped. Forget about it.
Like l said previously (and was brushed down on AFF) - the vaccination hubs should be going 24/7 - 365 - until demand subsides.
I'm down in Melbourne for work atm and coincidentally on nightshift. Me and a few work colleagues would go at 2am for the jab, but out of luck....
ROLL IT OUT
Keep in mind the ATAGI advice is not strictly 21 days for Pfizer.If they aren't confirming second dose timing upfront, there is a huge risk of people not being able to get appointments for second dose at the recommended interval.
The recommended interval between two doses of Comirnaty is at least 21 days. The minimum acceptable interval between the two doses is 19 days. It is recommended to complete the two-dose course within 6 weeks. This allows time for logistical considerations, including supply and timing of access to vaccine at the individual and clinic levels. These limits are based on the intervals between doses studied in clinical trials.
Shortening of the minimum acceptable interval may result in a sub-optimal immune response. If two doses have inadvertently been given at a shorter than the minimum acceptable interval, it is not currently recommended that a vaccine dose is repeated. This is because there are no data on administration of more than two vaccine doses and there is still a likelihood of good protection in that individual.
Longer intervals between first and second doses may need to be recommended during program rollout if epidemiological considerations warrant a change (e.g. during an outbreak response to ensure available doses are provided as first doses to as many people as possible). If the second dose of Comirnaty is administered later than the recommended interval, no further doses are required.
Although Comirnaty may provide partial protection against COVID-19 as soon as 12 days after the first dose, this protection is likely to be short lived. A two-dose course is recommended for optimal protection.
In clinical trials, the timing of administration of COVID-19 Vaccine AstraZeneca ranged from approximately 4 weeks up to 26 weeks. In a post-hoc analysis, vaccine efficacy following the second dose of COVID-19 Vaccine AstraZeneca progressively increased with a longer interval between doses and appeared to be greatest when the interval was ≥12 weeks.
Short-term efficacy from 3 weeks after the first dose, before the second dose and up to 12 weeks post vaccination was about 73% (95% CI: 48.79–85.76).39Also refer to the Vaccine information section for further information. Short term efficacy from 22 days until 90 days after a single dose was 76% (95% CI: 59·3–85·9). The duration of protection after a single dose has not yet been established, and a second dose is recommended for optimal protection.
Shortening the interval from 12 weeks to no less than 4 weeks between doses is acceptable and may be appropriate in certain circumstances, for example, imminent travel or anticipated risk of COVID-19 exposure. If a dose has been inadvertently given before the minimum 4-week interval, it is not currently recommended that the vaccine dose be repeated.
If the second dose of COVID-19 Vaccine AstraZeneca is administered later than the recommended interval, no further doses are required.
My daughter had a very big gap between her Pfizer jabs - she had her first jab in London in early January. Left earlier than expected due to flight cancellations and having to take whatever she could get. Then between hotel quarantine and when her new hospital started vaccinating, she probably had a 7 week gap. No one seemed to feel it was too much of a issue, although she was prioritised to get her second jab.Keep in mind the ATAGI advice is not strictly 21 days for Pfizer.
And similar with AstraZeneca.
See pages 12 & 13 of the latest clinical guidance.
I will let this wave of calls to the vaccine hotline in Victoria pass before booking for my second jab. Would rather more get started on a dose to be honest, before I go back for a second.
My daughter had a very big gap between her Pfizer jabs - she had her first jab in London in early January. Left earlier than expected due to flight cancellations and having to take whatever she could get. Then between hotel quarantine and when her new hospital started vaccinating, she probably had a 7 week gap. No one seemed to feel it was too much of a issue, although she was prioritised to get her second jab.
Study behind that was only for older people.
Concerns remain about effectiveness in older adults On 30 December 2020, the UK announced a deviation from the recommended protocol for the Pfizer-BioNTech covid-19 vaccine, prolonging the interval between doses from 3 to 12 weeks.12 Similar decisions were made for the Oxford-AstraZeneca...www.bmj.com
Pfizer recommendation is still 3wks between doses.
Mind you the UK is juggling efficacy and ensuring people don't get Covid.
Certainly all the Drs I've spoken to here have the view efficacy for Pfizer is still better at 8+ weeks based on real world data they're seeing.
But US are doing 21 days for Pfizer and 28 for Moderna - if 3 weeks was too short wouldn't we be seeing a move to change things in the USA? The USA has a much larger population and have given a lot more mrna doses than UK.
the rate of cases, hospitalisations, deaths
And have had a lot higher proportion of vaccinated people hospitalised and dying.But US are doing 21 days for Pfizer and 28 for Moderna - if 3 weeks was too short wouldn't we be seeing a move to change things in the USA? The USA has a much larger population and have given a lot more mrna doses than UK.
If you ask any of the vaxxers in the UK they'd say 7 weeks was too early, regardless of Pfizer or AZ they recommend a minimum of 8 weeks between each jab for better efficacy rates. 12 is still preferred, although in the last 2 weeks they have brought lots forward closer to the 8 week mark.