According to ADS-B data the aircraft achieved 185 knots over ground near the aiming markers runway 35L still on the runway centerline but never became airborne.
According to pictorial evidence engine #1 (left hand engine, CF6) separated the airframe during rotation for takeoff, the departure of that engine may also have failed the center engine #2.
The FAA reported: "UPS Flight 2976 crashed around 5:15 p.m. local time on Tuesday, Nov. 4, after departing from Louisville Muhammad Ali International Airport in Kentucky. The McDonnell Douglas MD-11 was headed to Daniel K. Inouye International Airport in Honolulu. The FAA and NTSB will investigate."
Ground observers reported the aircraft had been delayed for about two hours for work on the left hand engine (engine #1), the engine #1 separated during the takeoff run, the center engine emitted streaks of flames, the aircraft impacted a UPS warehouse and ploughed through other facilities before coming to rest in a large plume of fire and smoke.