General Discussion/Q&A on Coronavirus (COVID-19)

[lovetravellingoz]

Dexamethasone has been reported in the UK to in serious patients reduce the mortality rate :

In one study, the drug cut the risk of death by a third for Covid-19 patients on ventilators and by a fifth for those on supplemental oxygen.

https://twitter.com/i/web/status/1272870950955032579

Coronavirus: Dexamethasone proves first life-saving drug

Patients should be given the cheap drug without delay, after "fantastic" trial results, experts say.

www.bbc.com

Potentially lifesaving coronavirus treatment dexamethasone could have 'immediate impact,' former FDA chief says

"It's going to probably have an immediate impact on what doctors are doing in the ICU setting," Gottlieb said Tuesday on CNBC's "Squawk Box" in response to the news.

www.cnbc.com

COVID-19 treatment a 'major breakthrough'

A cheap and widely used steroi_ called dexamethasone has become the first drug shown to be able to save liv...

www.9news.com.au

 

[drron]

So some more emerging evidence about the virus.
First it was almost certainly present in Europe in December 2019 with evidence now from Italy added to the french reports.Sewerage began showing virus particles in Milan and Turin effluent on 18/12/19.

Coronavirus was already in Italy by December, waste water study finds

Scientists say samples from Milan and Turin showed virus traces long before cases were confirmed.

www.bbc.com

Next evidence that the viral mutation found in Europe and the USA is more infective than the Wuhan strain of the virus.

Welcome to Precision Vaccinations News

Precision Vaccinations News publishes vaccine news patients can trust to make informed immunization decisions in partnership with doctors, nurses, and pharmacists.

www.coronavirustoday.com

 

[drron]

Cancer researchers come up with more targets for a vaccine.

Welcome to Precision Vaccinations News

Precision Vaccinations News publishes vaccine news patients can trust to make informed immunization decisions in partnership with doctors, nurses, and pharmacists.

www.coronavirustoday.com

And the NIH is setting up a collaborative effort to learn more about Covid to predict things such as who might develope severe disease and are different treatments have specific areas that they might be more effective in treating.

Analytics Platform Harnesses COVID-19 Patient Data

National COVID Cohort Collaborative platform helps scientists analyze disease and develop treatments

www.coronavirustoday.com

 

[Pushka]

Cancer researchers come up with more targets for a vaccine.

Welcome to Precision Vaccinations News

Precision Vaccinations News publishes vaccine news patients can trust to make informed immunization decisions in partnership with doctors, nurses, and pharmacists.

www.coronavirustoday.com

And the NIH is setting up a collaborative effort to learn more about Covid to predict things such as who might develope severe disease and are different treatments have specific areas that they might be more effective in treating.

Analytics Platform Harnesses COVID-19 Patient Data

National COVID Cohort Collaborative platform helps scientists analyze disease and develop treatments

www.coronavirustoday.com

Diabetes and obesity was thought about right at the beginning and it still seems to be one of the highest risk factors.

 

[drron]

More on treatment of Covid.
First with Dexamethasone.What wasn't said was that if given to patients that didn't need oxygen therapy the trend was to an increased mortality rate.

.

And since then there is a worry that supply might not keep up to demand especially with the injectable formulation which is necessary for the most severe cases being ventilated.And this is the group with the best results.

Science | AAAS

www.sciencemag.org

Back to hydroxychloroquine.note that image above also gives the result of their trial with this drug which ended the hydroxychloroquine story.but the increase in mortality first of all didn't reach statistical significance.but more importantly was the dosage of hydroxychloroquine used.2400mg in the first 24 hours.This is a massively toxic dose and 6 times the recommended dose to avoid cardiac toxicity.some medical commentators are now using the word negligence.

But a new drug-one of the biologicals.

Study finds GM-CSF blockade with mavrilimumab improved outcomes in non-intubated COVID-19 patients

Inhibiting granulocyte–macrophage colony-stimulating factor (GM-CSF) signalling may offer a therapeutic benefit in patients suffering from severe coronavirus disease 2019 (COVID-19) pneumonia and systemic hyperinflammation, according to a study published in The Lancet Rheumatology.Preliminary...

dgalerts.docguide.com

 

[p--and--t]

It has been previously reported that it seemed more males than females seem to suffer the worst of the effects of the virus and now I see reports that more bald people suffer than those who are more hirsute. Theories being postulated it may have something to do with hormone imbalance in ageing males effecting the immune system deleteriously.

So watch out if you are old male and bald(ing)

Could there be a link between baldness and coronavirus?

Two small studies published recently suggested bald men were over-represented in those in hospital with COVID-19. While this may sound strange, science does offer a plausible explanation, writes Jenny Graves.

www.abc.net.au

 

[Pushka]

More on treatment of Covid.
First with Dexamethasone.What wasn't said was that if given to patients that didn't need oxygen therapy the trend was to an increased mortality rate.

View attachment 221010.

And since then there is a worry that supply might not keep up to demand especially with the injectable formulation which is necessary for the most severe cases being ventilated.And this is the group with the best results.

Science | AAAS

www.sciencemag.org

Back to hydroxychloroquine.note that image above also gives the result of their trial with this drug which ended the hydroxychloroquine story.but the increase in mortality first of all didn't reach statistical significance.but more importantly was the dosage of hydroxychloroquine used.2400mg in the first 24 hours.This is a massively toxic dose and 6 times the recommended dose to avoid cardiac toxicity.some medical commentators are now using the word negligence.

But a new drug-one of the biologicals.

Study finds GM-CSF blockade with mavrilimumab improved outcomes in non-intubated COVID-19 patients

Inhibiting granulocyte–macrophage colony-stimulating factor (GM-CSF) signalling may offer a therapeutic benefit in patients suffering from severe coronavirus disease 2019 (COVID-19) pneumonia and systemic hyperinflammation, according to a study published in The Lancet Rheumatology.Preliminary...

dgalerts.docguide.com

One of the mabs. I understand supply is tricky.

 

[nutwood]

I've just come to the realisation that COVID 19 is almost perfectly tailored to news cycles.
First report; "New cases detected"
Second report" Many new cases detected"
Third report " Premier forecasts harsh measures due to new cases detected"
Fourth report" Explosion of new cases blamed upon.... (insert villain here)"
Fifth report" Delays in re-opening AFL blamed upon.... (insert villain here)"
RESET: Totally inconsequential report; Bill Shorten videoed feeding seagulls..?
First report; "New cases detected"......

 

[Hvr]

So watch out if you are old male and bald(ing)

I've got the trifecta above, and hit the quadrella by living in a COVID-19 hot spot.

 

[lovetravellingoz]

I've got the trifecta above, and hit the quadrella by living in a COVID-19 hot spot.

Well hopefully to offset some of that you have Type O blood.

 

[Hvr]

Well hopefully to offset some of that you have Type O blood.

That's a positive then. 🅾

 

[VPS]

Oh dear - they are still out there

 

[lovetravellingoz]

Oh dear - they are still out there

I think she did very well.

I mean that must be a Guinness World Record for the number of conspiracy theories raised in a 2 minute time span.

 

[Pushka]

Oh dear - they are still out there

And she is so young and so many years left to "influence".

I think getting "temperatured" sounds rather grim though.

 

[drron]

Many drugs are now being investigated for possible benefit in the treatment of Covid 19 including cough and Thalidomide.Some common drugs such as statins and brufen seem to help as well but they are from observation trials not a trial setting out to use those drugs for benefit.Observation trials are regarded as less accurate.

https://dnascience.plos.org/2020/03...-19-from-cough-to-thalidomide-to-cough-syrup/

In-hospital use of statins associated with reduced mortality risk in patients with COVID-19

The use of statins appears to be associated with a lower mortality risk and a lower incidence of mechanical ventilation in patients hospitalised with coronavirus disease 2019 (COVID-19), according to a study published in Cell Metabolism.The large-scale retrospective study also showed that...

dgalerts.docguide.com

 

[VPS]

And there is another one

“I Don’t Wear A Mask For Same Reason I Don’t Wear Underwear, Things Gotta Breathe” – Florida Woman Tells Off County Commissioners - NewsBreak

It’s an absolute coughshow down in Florida… then again, when is it not?. According to CBS 12, the Palm Beach County commissioners unanimously approved an...

www.newsbreak.com

 

[drron]

The USA is now investing in better tests.less invasive but also rapid answers getting down to 15 minutes.They are now testing 400K to 900K per day.

Welcome to Precision Vaccinations News

Precision Vaccinations News publishes vaccine news patients can trust to make informed immunization decisions in partnership with doctors, nurses, and pharmacists.

www.coronavirustoday.com

As well the border crossers rounded up by ICE now are segreagated for 14 days and offered testing.

Welcome to Precision Vaccinations News

Precision Vaccinations News publishes vaccine news patients can trust to make informed immunization decisions in partnership with doctors, nurses, and pharmacists.

www.coronavirustoday.com

With more extensive use of antibody testing the CDC now thinks actual cases could be 10 times the official count.

CDC says COVID-19 cases in U.S. may be 10 times higher than reported

The estimate comes from a nationwide look at antibody tests.

www.nbcnews.com

And more evidence that Covid 19 is more persistent than SARs or MERs.

Welcome to Precision Vaccinations News

Precision Vaccinations News publishes vaccine news patients can trust to make informed immunization decisions in partnership with doctors, nurses, and pharmacists.

www.coronavirustoday.com

And another -mab that seems effective in treatment.

Larger study backs tocilizumab use to cut risk of mechanical ventilation, death in severe COVID-19

Results from an Italian study published in The Lancet Rheumatology have demonstrated a significant reduction in the risk of invasive mechanical ventilation or death in patients with severe coronavirus disease 2019 (COVID-19) pneumonia who were treated with the IL-6 inhibitor tocilizumab, either...

dgalerts.docguide.com

 

[TheRealTMA]

Surprise surprise. As we generally all knew we were soLs sold a pup but they refused to be honest with the public.

'Dishonest': COVIDSafe app has not detected a case despite 6 million downloads

As COVID infections soar in Victoria, the federal government's COVIDSafe app has not identified a single close contact of a person infected with the coronavirus in two months.

www.theage.com.au

 

[Pushka]

Surprise surprise. As we generally all knew we were soLs a pup but they refused to be honest with the public.

'Dishonest': COVIDSafe app has not detected a case despite 6 million downloads

As COVID infections soar in Victoria, the federal government's COVIDSafe app has not identified a single close contact of a person infected with the coronavirus in two months.

www.theage.com.au

I thought I heard it had only detected one case where normal tracing had not similarly picked it up. But if people won't download then of course it won't work. Not sure that's the apps fault though.

 

[TheRealTMA]

I thought I heard it had only detected one case where normal tracing had not similarly picked it up. But if people won't download then of course it won't work. Not sure that's the apps fault though.

Unfortunately the problem is that the app is basically useless. (And govt tech advisors knew it but they persisted with the falsehood to make people think they had a solution.)