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If you're flying First, then I'd suggest JFK on AA or Newark on United. Much better hard products on the actual flights to SFO that way.
You lost me there! first, hard products?
I will be leaving from Lower Manhattan.
It depends where your going. The A and E trains serve JFK (from different stations on the JFK Airtrain - Howard Beach and Jamaica Station). They have different routes into Manhattan and can take 40-60 mins to get there.Thank's for the replies, in this case I will probably stick with JFK if there is no substantial difference, maybe try the subway instead of shuttle option to get there.