Not necessarily ... if you only have $50/$100 notes maybe you just are very wealthy and don't need small bills! Or you've just come from Las Vegas and used all your small $$$ in the airport slots.
If you do ever get all $50 / $100 bills, be sure sure you are getting them from a trusted source ... still getting lots of counterfeit bills in circulation, usually in the $20 and up category. Don't be surprised to see the cashier look at them and use a pen to test the paper.
If you haven't seen the newer currency recently, doesn't hurt to do a little research and get familiar with the security features (colors, threads, etc).