This was my grand tour of South America (not-Brazil) which may give you some ideas:
Following in the footsteps of, and inspired by a number of AFFers (hi JohnM, dr.ron/mrsdr.ron, kpc and others

) I'm going round (western) South America for a month, mostly on LAN, but a bit of Avianca and even TAME.
The schedule is:
HBA-SYD VA Y
SYD-AKL-SCL LAN J
Overnight Santiago Novotel
SCL-GYE-UIO LAN PE
4 nights Quito Mercure, seeing the city and touring the volcanos to the south (although the weather forecast is lousy)
UIO to Coca TAME Y
3 nights at Sacha Lodge, a rainforest lodge in the eastern Ecuadorian rainforest
Coca to Quito TAME Y
UIO-GYE-GPS (Baltra, Galapagos...
This driving trip and a cruise south of Puerto Montt - the Lake District of Chile and Argentina there I'd especially recommend.
If trip reports had a sub title, this one would be "When trip reports Collide"
Today I start on a trip to South America which involves two different AFF meet-ups.
First, the flights:
Virgin Australia domestic, then LATAM Sydney to Santiago via Auckland, then back with stops in Easter Island and Tahiti and then Air New Zealand onwards to Melbourne via Auckland again. Business except the domestic legs. I'm doing most of the trip with a couple of friends. If anyone is in the SYD Qantas Flounge Monday morning, I'd so much appreciate some-one guesting in one of my...
My own Antarctic cruise and what I did before
I haven't begun this TR until I'm sitting here in the Qantas F Lounge at Sydney, waiting for my flight to Santiago, mainly because there have been so many issues to date, I wondered if I'd ever make it this far.
But what is planned:
Flights are all revenue, except the VA one first.
HBA-SYD, VA J
SYD-SCL , QF J
SCL-MVD, LATAM Y (bumped to the next day due to late SYD-SCL, was originally booked PE

)
MVD-SCL LATAM PE
SCL-PWU Charter flight, effectively Eurobusiness
Cruise
PWU-SCL charter, 'Eurobusiness'
SCL-SYD, QF J
SYD-HBA, VA J
Cruise is SilverSeas, 19 days...
Mendoza in Argentina is a 'must' if you like your wines
Well, the title is mostly a lie, sorry. Not a good start. It was a work trip, but I couldn't resist the snazzy trip title.

There wasn't a lot of chilling out at all, but rather a number of long drives, 4WDing over some atrocious tracks and some mild mountain-side climbing, checking out mineral areas. For those who have seen my figure, the latter may seem unlikely! But it was in a very scenic part of southern Chile so I thought I'd share what I can.
Guaranteed to be off the tourist trails!
I rarely go back to an area where I've visited ... too much of the world unseen! But...