General Medical issues thread

[Quickstatus]

Yes Three times a day, easier to take but why would people say it works better (more efficacious) rather than just easier to take

Interestingly no one has managed to determine the mechanism of action of paracetamol. We know it works but not how. Same with anaesthesia.

There is really good evidence on the other hand that says Nurofen Zavance is more effective than bog standard Nurofen because it's a different formulation and absorption is much faster.

 

[TheRealTMA]

Being higher dose (665 vs 500mg and I think slower release) it means 3 doses a day 8 hrs apart to get 24 hr coverage rather than needing to take a 4th dose in the middle of the night to get 24 hr coverage. I take mine at 7am, 4pm and 10 +/-pm

I find a single malt to wash down the paracetamol is useful.

 

[TheRealTMA]

Yes Three times a day, easier to take but why would people say it works better (more efficacious) rather than just easier to take

Interestingly no one has managed to determine the mechanism of action of paracetamol. We know it works but not how. Same with anaesthesia.

There is really good evidence on the other hand that says Nurofen Zavance is more effective than bog standard Nurofen because it's a different formulation and absorption is much faster.

FWIW. My old GP expressed severe caution with Nurofen (ibuprofen) in older patients.

 

[VPS]

FWIW. My old GP expressed severe caution with Nurofen (ibuprofen) in older patients.

what did he say about the single malt?

 

[TheRealTMA]

what did he say about the single malt?

Use in moderation.

 

[VPS]

Use in moderation.

Good thing you listen to him then

 

[RooFlyer]

Yes Three times a day, easier to take but why would people say it works better (more efficacious) rather than just easier to take

Dunno, but possibly because it was working better from them, as they weren't missing a dose and were getting a 24hr effect rather than stop/start if they missed the early morning dose f they chose 500mg.

 

[Quickstatus]

stop/start

Though the blood levels of paracetamol is actually more predictable in bog standard paracetamol, this is because the modified release Paracetamol absorption is unpredictable It can actually take more than 24hrs to dissolve in some people. It has 2 layers - the outer layer of the tablet is quick dissolving but it has an inner layer which is slow dissolving.

The risk of overdosage is actually higher as a result - which is why Panadol osteo is "pharmacist only" in AU/NZ

 

[drron]

I guess I am a slow dissolver. I take 2 Panadol Osteo in the morning with good effect. Taking a second dose up until 2000 has absolutely no extra effect so I continue with just my daily dose.